Evolution of physiological pH 6 . 8 bicarbonate buffer systems : application to the dissolution testing of enteric products
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چکیده
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منابع مشابه
In vitro dissolution of proton-pump inhibitor products intended for paediatric and geriatric use in physiological bicarbonate buffer.
Proton-pump inhibitor (PPI) products based on enteric coated multiparticulates are design to meet the needs of patients who cannot swallow tablets such as children and older adults. Enteric coated PPI preparations exhibit delays in in vivo absorption and onset of antisecretory effects, which is not reflected by the rapid in vitro dissolution in compendial pH 6.8 phosphate buffer commonly used f...
متن کاملRealistic and discriminative in vitro release in pH 6.8 [B] physiological bicarbonate buffer compared to [A] compendial phosphate buffer for enteric coated formulations
and discriminative in vitro release in pH 6.8 [B] physiological bicarbonate buffer compared to [A] compendial phosphate buffer for enteric coated formulations
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Development of an oral in vivo predictive dissolution medium for acid drugs with a pKa in the physiological range (e.g., Biopharmaceutics Classification System Class IIa) requires transport analysis of the complex in vivo CO2 /bicarbonate buffering system. In this report, we analyze this buffer system using hydrodynamically defined rotating disk dissolution. Transport analysis of drug flux was ...
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1-Introduction Travertines are limestones that form where hot groundwaters rich in calcium and bicarbonate emerge at springs. Travertines cover a large area southwest of Azarshahr (East Azarbaijan province), in some parts of which active springs are currently settling travertine. One of the main questions about travertine springs is their origin, as well as the secondary processes that have ch...
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Enteric coatings are widely used in formulations of drug delivery spheres. The coating protects an active pharmaceutical ingredient (API) from acidic conditions in the low pH environment of the stomach. The coating breaks down readily at higher pH in the lower intestine to allow absorption of the API. The thickness of the enteric coating is one of the factors that determine the release rate of ...
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